Evidence for impaired lipolysis in abdominally obese men: postprandial study of apolipoprotein B-48– and B-100–containing lipoproteins
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چکیده
منابع مشابه
Plasma apolipoprotein B-48 transport in obese men: a new tracer kinetic study in the postprandial state.
CONTEXT The mechanisms responsible for impaired chylomicron metabolism have not been adequately investigated in obese subjects. OBJECTIVE We aimed to compare apolipoprotein (apo) B-48 kinetics in obese and lean men by developing a new model to describe the kinetics of apoB-48 particles in the postprandial state. DESIGN, SETTING, AND PATIENTS Seven obese and 13 age-matched lean men were give...
متن کاملApolipoprotein B-48 and retinyl palmitate are not equivalent markers of postprandial intestinal lipoproteins.
This study compared retinyl palmitate and apolipoprotein (apo) B-48 as markers of postprandial triglyceride-rich lipoproteins. Nine non-diabetic men received an oral vitamin A-containing fat load. We measured retinyl palmitate, apoB-48, apoB-100, and triglyceride levels in Sf > 400, Sf 60-400 and Sf 20-60 lipoproteins. The peak retinyl palmitate concentration was delayed compared to the peak ap...
متن کاملEvidence of increased secretion of apolipoprotein B-48-containing lipoproteins in subjects with type 2 diabetes.
Patients with type 2 diabetes have high levels of triglyceride-rich lipoproteins (TRLs), including apolipoprotein B-48 (apoB-48)-containing TRLs of intestinal origin, but the mechanism leading to overaccumulation of these lipoproteins remains to be fully elucidated. Therefore, the objective of this study was to examine the in vivo kinetics of TRL apoB-48 and VLDL, intermediate density lipoprote...
متن کاملApolipoprotein B 100 and 48
Apolipoprotein B is the main structural surface protein found on all beta-lipoproteins (Chylomicrons, VLDLs, IDLs and LDLs). There is a single molecule of apoB on each of those lipoproteins. It is the only apolipoprotein that is not transferablei.e. it is with the particle from its birth till its death. Beta-lipoproteins are the lipoproteins capable of trafficking cholesterol into the artery wa...
متن کاملLipoprotein lipase bound to apolipoprotein B lipoproteins accelerates clearance of postprandial lipoproteins in humans.
OBJECTIVE Experiments in cells and animal models show that lipoprotein lipase (LpL) bound to apolipoprotein (apo)B lipoproteins enhances their uptake by receptor mediated pathways. It is unknown whether this pathway is important in humans. METHODS AND RESULTS ApoB lipoproteins with LpL were isolated from normal subjects after oral fat loading by immunoaffinity chromatography and were further ...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2002
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/76.2.311